Synopsis: Exercise intolerance and blunted cardiac output response to exercise in pulmonary hypertension is related to an impaired right ventricular exertional contractile reserve. Source: Spruijt OA, Man FS, Groepenhoff H, et al. The effects of exercise on right ventricular contractility and right ventricular-arterial coupling in pulmonary hypertension. Am J Respir Crit Care Med. 2015; 191:1050-1057. (Source: Clinical Pulmonary Medicine)