Conclusion The findings of this study should be interpreted carefully, particularly as the six observational studies included in the review had variable

results: three had found a significant association between pregnant paracetamol use and wheeze, and three did not. While the odds ratio when pooling these six results found a statistically significant association, this finding should also be considered in light of some important limitations: The review categorised paracetamol use in each study as either ‘yes’ or ‘no’. Only one of the pooled studies specifically looked at paracetamol use during the latter half of pregnancy (20-32 weeks).

This, along with wide differences in the categorisation of paracetamol doses in the individual studies, means that when pooling the results, onl...