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Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial

Background: Fluticasone furoate (FF) is a novel long-acting inhaled corticosteroid (ICS). This double-blind, placebo-controlled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or in the evening, and FF 200 mcg twice daily (morning and evening), for 8 weeks in patients with persistent asthma. Methods: Asthma patients maintained on ICS for [greater than or equal to]3 months with baseline morning forced expiratory volume in one second (FEV1) 50-80% of predicted normal value and FEV1 reversibility of [greater than or equal to]12% and [greater than or equal to]200 ml were eligible. The primary endpoint was mean change from baseline FEV1 at week 8 in pre-dose (morning or evening [depending on regimen], pre-rescue bronchodilator) FEV1....

New Method To Diagnose Sinusitis Could Reduce Use Of Antibiotics

A new method of diagnosing sinusitis is presented in a new thesis from Lund University. The results offer the potential to reduce the use of antibiotics and the costs of the disease to society. Sinusitis is a very common disease and exists in both an acute and a chronic form. In Europe, over nine per cent of the population suffers from chronic sinusitis. The author of the thesis is Pernilla Sahlstrand Johnson, a PhD student and ear, nose and throat doctor at Lund University and Skåne University Hospital... (Source: Health News from Medical News Today)

Relationships Between Airway Hyperresponsiveness, Inflammation, and Calibre in Asthma

Conclusions  We found no relationship between airway inflammation and calibre, whilst showing significant relationships between AHR and airway calibre and AHR and airway inflammation. Whilst relationships exist, the lack of complete concordance highlights the important role each contributes to the assessment of the asthmatic individual. Content Type Journal ArticlePages 1-5DOI 10.1007/s00408-011-9328-xAuthors Philip M. Short, Division of Medical Sciences, Asthma and Allergy Research Group, Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY UKSamuel I. W. Lipworth, Bute Medical School, University of St. Andrews, College Gate, St. Andrews, Fife, KY16 9AJ UKBrian J. Lipworth, Division of Medical Science...

How Useful Are Statins for Treating Acute Lung Injury?How Useful Are Statins for Treating Acute Lung Injury?

How did ICU patients respond when treated with statins to prevent and treat acute lung injury and acute respiratory distress syndrome? Medscape Critical Care (Source: Medscape Today Headlines)

Dosimetric consequences of tumour motion due to respiration for a scanned proton beam.

Authors: Kraus KM, Heath E, Oelfke U Abstract A method for simulating spot-scanned delivery to a moving tumour was developed which uses patient-specific image and plan data. The magnitude of interplay effects was investigated for two patient cases under different fractionation and respiratory motion variation scenarios. The use of volumetric rescanning for motion mitigation was also investigated. For different beam arrangements, interplay effects lead to severely distorted dose distributions for a single fraction delivery. Baseline shift variations for single fraction delivery reduced the dose to the clinical target volume (CTV) by up to 14.1 Gy. Fractionated delivery significantly reduced interplay effects; however, local overdosage of 12.3% compared to the statically delivered do...

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