News release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine Commentaries: Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre People […]
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Heterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv Commentary: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News Commentary on Twitter So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic […]
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Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review – JAMA Network Open Commentaries: Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP Expert reaction to systematic review on rates of postacute sequelae of SARS-CoV-2 infection (PASC) – Science Media Centre How many people get ‘long COVID’? More […]
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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv Commentary: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical Related: RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths. Opinion | The mRNA vaccines are extraordinary, but Novavax […]
The post [Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients. appeared first on Links Medicus.
Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens Commentary: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology Commentaries on Twitter When exposed to #SARSCoV2 why does one person have no illness, while another is soon in ICU?Dose.Controlled study in monkeys shows the dose of viruses inhaled is […]
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A primer on what we know about mixing and matching Covid vaccines – STAT Related: Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination. RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine. Another study shows increased immune response with […]
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WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups – CIDRAP See also: WHO advises additional COVID shot for immunocompromised people – Reuters
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How antiviral pill molnupiravir shot ahead in the COVID drug hunt – Nature Related: What we know — and don’t know — about Merck’s new Covid-19 pill. [Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with […]
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Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
The post Cluster RCT: An antimicrobial stewardship intervention safely reduced the use of broad-spectrum antibiotics among patients hospitalized with moderately severe community-acquired pneumonia. appeared first on Links Medicus.
D-Dimer Testing for the Exclusion of Pulmonary Embolism Among Hospitalized Patients With COVID-19 – JAMA Network Open Commentary: D-Dimer Level Not Useful for Ruling Out PE in COVID-19 Patients – HealthDay
The post D-Dimer testing for the exclusion of pulmonary embolism has limited clinical utility among hospitalized patients with COVID-19 – most patients with or without pulmonary embolism have increased levels. appeared first on Links Medicus.