‘Strong evidence’ for causal link between parental smoking, childhood asthma
Parental smoking is associated with symptoms of asthma in exposed children, report researchers who found the more parents smoked, the greater the risk to their children.
Sté Tunisienne des Maladies Respiratoires et d'Allergologie
Cercle des Bureaux - Appartement B 5-3 . 1082 Centre urbain Nord Tunis
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Swine-flu deaths far greater than reported
The true number of deaths from the 2009 H1N1 “swine flu” pandemic may be 15 times higher than the number confirmed by laboratory testing and previously reported to the World Health Organization, study findings indicate.
Measurement of asthma control according to 2006 Global Initiative on Asthma Guidelines: MAGIC Study
Background:
Asthma Control Questionnaire (ACQ) is a validated tool to measure asthma control. Cut-off points that best discriminate "well-controlled" or "not well-controlled" asthma have been suggested from the analysis of a large randomized clinical trial but they may not be adequate for daily clinical practice. Aims:To establish new cut-off points of the ACQ that best discriminate the control degree according to global initiative on asthma guidelines(GINA) 2006 guidelines in patients with asthma managed at Allergology and Pulmonology Departments as well as Primary Care Centers in Spain.MethodS: An epidemiological descriptive study, with prospective data collection. Asthma control following GINA-2006 classification and 7-item ACQ was assessed. The study population was split in two parts: ...
Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium
In conclusion, it is important when reporting a clinical trial to be transparent about who was blinded and how the blinding was performed; if the design is open-label, additional efforts must be made to minimise risk of bias. If these recommendations are followed, and the data are considered in the full knowledge of any potential sources of bias, results with tiotropium suggest that data from open-label studies can provide valuable and credible evidence of the effects of therapy.
In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis
Conclusions:
Bacterial infection of the bronchial tree is common in persistent preschool wheezers andprovides a possible explanation for non response to ICS therapy. Non-typeable H. influenzaeseems to be the predominant pathogen involved, followed by S. pneumoniae and M.catarrhalis. (Source: BMC Pediatrics - Latest articles)