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Métastase cardiaque d’un carcinome épidermoïde bronchique

Publication year: 2012
Source:Revue de Pneumologie Clinique

L. Herrak, M. Bouchikh, M. Maidi, H. Fennane, F. Ouchen, A. Benosmane

Les localisations secondaires du cancer du poumon sont fréquentes mais la localisation cardiaque est rare et souvent de diagnostic post-mortem. Nous rapportons un cas d’un patient de 67ans, sans antécédents pathologiques particuliers en dehors d’un tabagisme chronique, porteur d’un carcinome épidermoïde bronchique et dont le bilan d’extension retrouve une localisation secondaire intra-auriculaire gauche. À travers cette observation, les auteurs proposent une mise au point sur cette localisation rare et exceptionnelle. Secondary location of lung cancer are frequent but the location heart is rare and often diagnosed postmortem. We report a case of a patient of 67 years without disease history, individuals smoking outside a chronic carrier of bronchial squamous cell carcinoma and the staging of which finds a secondary location within the left atrial. Through this observation, the authors propose an update on this rare and exceptional location.




Efficacy of inhaled N‐acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis

Conclusions:  These findings indicate that NAC monotherapy may have some beneficial effect in patients with early stage IPF. Further trials in more select IPF populations with progressive disease are required to prove the efficacy of inhaled NAC. (Source: Respirology)

The health impact and toxicological effects of nanomaterials in the lung

ABSTRACTThe manufacture, use and disposal of nanomaterials will result in increased human exposures to engineered nanoparticles (ENPs), potentially via the lung. ENPs differ physically and chemically from natural or combustion derived nanoparticles (NPs) in important respects. While there are parallels with ultrafine aerosol particles in the atmosphere and colloids in water, there remain some unique issues and impacts of engineered materials on lung health that require consideration and urgent study.The study of toxicity of nanomaterials in biological systems nanotoxicology emerged from the observed effects of inhaled particulate matter (PM) and NPs. Some engineered nanomaterials deserve special toxicological examination because of their unique properties in biological systems; novel toxic...

Emerging evidence of Epithelial‐to‐Mesenchymal Transition in lung carcinogenesis

ABSTRACTThe epithelial‐to‐mesenchymal transition (EMT) is a developmental program that regulates embryonic morphogenesis and involves significant morphological and molecular changes in cells. Experimental models have revealed that EMT also contributes to various malignant features of cancer cells, including motile, invasive, anti‐apoptotic and stem‐like phenotypes. Clinically, correlative studies have indicated that mesencymal‐like features of tumor cells are associated with poor tumor differentiation as well as worse patient prognosis. Nevertheless, due to its transitory nature, demonstration of an actual occurrence of EMT during human carcinogenesis is challenging, and most of the evidence to date has been limited to breast and colorectal cancers. However, recent studies sugges...

Increased Neutrophil Migration in Smokers with or without Chronic Obstructive Pulmonary Disease (COPD)

Conclusions:  Chemotaxis of circulating neutrophils towards CXCL‐8, and partly towards LTB4, is increased in smokers, indicating a systemic influence of smoking on cell activation, irrespective of the presence of airflow limitation. The relationship between TNF‐α and chemotactic response suggests that TNF α is involved in neutrophil activation, resulting in enhanced migration.© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology (Source: Respirology)

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